Synthesis of Novel Benzothiazole-Profen Hybrid Amides as Potential NSAID Candidates.

ABSTRACT: Herein, we report the synthesis of a series of new compounds by combining 2-aminobenzothiazole with various profens. The compounds were characterized using techniques such as ¹H- and ¹³C-NMR, FT-IR spectrometry, and high-resolution mass spectrometry (HRMS), with detailed HRMS analysis conducted for each molecule. Their biological activities were tested in vitro, revealing significant anti-inflammatory and antioxidant effects, comparable to those of standard reference compounds. Lipophilicity was experimentally determined through partition coefficient (R_M) measurements. To understand their binding affinity, molecular docking studies were perfsormed to analyze interactions with human serum albumin (HSA). The stability of these predicted complexes was further

SUBMITTER: Ivanov I 

PROVIDER: S-EPMC11721736 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature