Mean arterial pressure at the initiation of continuous renal replacement therapy as a prognostic indicator in patients with acute kidney injury.

ABSTRACT:

Background

Acute kidney injury (AKI) is a common complication in critically ill patients, with approximately 5% requiring continuous renal replacement therapy (CRRT). This study investigated the relationship between mean arterial pressure (MAP) and 28- and 90-day mortality in critically ill AKI patients treated with CRRT.

Methods

This secondary analysis of a bicenter, retrospective, observational study included patients with AKI who were treated with CRRT from January 2009 to September 2016. Mortality at 28 and 90 days post-CRRT initiation was analyzed using multivariate regression, generalized additive models, smooth curve fitting, and sensitivity analyses.

Results

A total of 1,142 patients were included, with 28-day and 90-day mortality rates of 62.1% and 71.8%, res

SUBMITTER: Song H 

PROVIDER: S-EPMC11721759 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature