A prognostic molecular signature of hepatic steatosis is spatially heterogeneous and dynamic in human liver.

ABSTRACT: Hepatic steatosis is a central phenotype in multi-system metabolic dysfunction and is increasing in parallel with the obesity pandemic. We use a translational approach integrating clinical phenotyping and outcomes, circulating proteomics, and tissue transcriptomics to identify dynamic, functional biomarkers of hepatic steatosis. Using multi-modality imaging and broad proteomic profiling, we identify proteins implicated in the progression of hepatic steatosis that are largely encoded by genes enriched at the transcriptional level in the human liver. These transcripts are differentially expressed across areas of steatosis in spatial transcriptomics, and several are dynamic during stages of steatosis. Circulating multi-protein signatures of steatosis strongly associate with fatty liver diseas

SUBMITTER: Perry AS 

PROVIDER: S-EPMC11722105 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature