Untargeted metabolome atlas for sleep-related phenotypes in the Hispanic community health study/study of Latinos.

ABSTRACT:

Background

Sleep is essential to maintaining health and wellbeing of individuals, influencing a variety of outcomes from mental health to cardiometabolic disease. This study aims to assess the relationships between various sleep-related phenotypes and blood metabolites.

Methods

Utilising data from the Hispanic Community Health Study/Study of Latinos, we performed association analyses between 40 sleep-related phenotypes, grouped in several domains (sleep disordered breathing (SDB), sleep duration, sleep timing, self-reported insomnia symptoms, excessive daytime sleepiness (EDS), and heart rate during sleep), and 768 metabolites measured via untargeted metabolomics profiling. Network analysis was employed to visualise and interpret the associations between sleep phenotypes and

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11722176 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature