Cxcl10 is required for survival during SARS-CoV-2 infection in mice.

ABSTRACT: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of the coronavirus disease 2019 (COVID-19) pandemic, remains endemic worldwide ~5 years since the first documented case. Severe COVID-19 is widely considered to be caused by a dysregulated immune response to SARS-CoV-2 within the respiratory tract. Circulating levels of the chemokine CXCL10 are strongly positively associated with poor outcome; however, its precise role in pathogenesis and its suitability as a therapeutic target have remained undefined. Here, we challenged 4-6 month old C57BL/6 mice genetically deficient in Cxcl10 with a mouse-adapted strain of SARS-CoV-2. Infected male, but not female, Cxcl10 ^-/- mice displayed increased mortality compared to wild type controls. His

SUBMITTER: Majumdar S 

PROVIDER: S-EPMC11722219 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature