IFN-<i>γ</i> signaling is required for the efficient replication of murine hepatitis virus (MHV) strain JHM in the brains of infected mice.

ABSTRACT: Neurotropic viruses are a major public health concern as they can cause encephalitis and other severe brain diseases. Many of these viruses, including flaviviruses, herpesviruses, rhabdoviruses and alphaviruses enter the brain through the olfactory neuroepithelium (ONE) in the olfactory bulbs (OB). Due to the low percentage of encephalitis that occurs following these infections, it's thought that the OBs have specialized innate immune responses to eliminate viruses. Murine hepatitis virus strain JHM (JHMV) is a model coronavirus that causes severe encephalitis in mice and can access the brain through olfactory sensory neurons. We've shown that a JHMV Mac1-mutant virus, N1347A, has decreased replication and disease in the brains of mice. Here we further show that this virus replicates poorl

SUBMITTER: Kerr CM 

PROVIDER: S-EPMC11722247 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature