TSPO-PET Reveals Higher Inflammation in White Matter Disrupted by Paramagnetic Rim Lesions in Multiple Sclerosis.

ABSTRACT:

Objective

To explore whether the inflammatory activity is higher in white matter (WM) tracts disrupted by paramagnetic rim lesions (PRLs) and if inflammation in PRL-disrupted WM tracts is associated with disability in people with multiple sclerosis (MS).

Methods

Forty-four MS patients and 16 healthy controls were included. 18 kDa-translocator protein positron emission tomography (TSPO-PET) with the ¹¹C-PK11195 radioligand was used to measure the neuroinflammatory activity. The Network Modification Tool was used to identify WM tracts disrupted by PRLs and non-PRLs that were delineated on MRI. The Expanded Disability Status Scale was used to measure disability.

Results

MS patients had higher inflammatory activity in whole brain WM compared to healthy controls

SUBMITTER: Tozlu C 

PROVIDER: S-EPMC11722250 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature