Single-base m⁶A epitranscriptomics reveals novel HIV-1 host interaction targets in primary CD4⁺ T cells.

ABSTRACT: N ⁶-methyladenosine (m⁶A) is the most prevalent cellular mRNA modification and plays a critical role in regulating RNA stability, localization, and gene expression. m⁶A modification plays a vital role in modulating the expression of viral and cellular genes during HIV-1 infection. HIV-1 infection increases cellular RNA m⁶A levels in many cell types, which facilitates HIV-1 replication and infectivity in target cells. However, the function of m⁶A modification in regulating HIV-1 infection of primary CD4⁺ T cells remains unclear. Here, we demonstrate that HIV-1 infection of Jurkat CD4⁺ T cells and primary CD4⁺ T cells promotes the interaction between the m⁶A writer complex subunits methy

SUBMITTER: Huang S 

PROVIDER: S-EPMC11722377 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature