A data-driven modeling framework for mapping genotypes to synthetic microbial community functions.

ABSTRACT: Microbial communities play a central role in transforming environments across Earth, driving both physical and chemical changes. By harnessing these capabilities, synthetic microbial communities, assembled from the bottom up, offer valuable insights into the mechanisms that govern community functions. These communities can also be tailored to produce desired outcomes, such as the synthesis of health-related metabolites or nitrogen fixation to improve plant productivity. Widely used computational models predict synthetic community functions using species abundances as inputs, making it impossible to predict the effects of species not included in the training data. We bridge this gap using a data-driven community genotype function (dCGF) model. By lifting the representation of each species t

SUBMITTER: Qian Y 

PROVIDER: S-EPMC11722394 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature