Gut Microbiota Interacts with Dietary Habits in Screenings for Early Detection of Colorectal Cancer.

ABSTRACT:

Background/objectives

Gut microbiota interacts with nutrients, which may be relevant to assigning a microbial signature to colorectal cancer (CRC). We aim to evaluate the potential of gut microbiota combined with dietary habits in the early detection of pathological findings related to CRC in the course of a screening program.

Methodology

The colonoscopy performed on 152 subjects positive for fecal occult blood test showed that 6 subjects had adenocarcinoma, 123 had polyps, and 23 subjects had no pathological findings. Gut microbiota was analyzed by 16S metagenomic. Caret package was used to build the classification models in R.

Results

Random forest (RF) classifier models were used to test the potential of gut microbiota alone or combined with dietary habits as a bio

SUBMITTER: Vega-Rojas A 

PROVIDER: S-EPMC11722828 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature