The associations among platelet count, mean platelet volume, and erectile dysfunction: an observational and Mendelian randomization study.

ABSTRACT:

Background

While previous studies have explored the associations and causalities among platelet count (PC), mean platelet volume (MPV), and erectile dysfunction (ED), further investigations are needed to clarify these relationships using advanced methodologies and analyzing specific populations.

Aim

To investigate the associations and causalities among PC, MPV, and ED using observational study and Mendelian randomization (MR) analysis.

Methods

A total of 114 patients with ED and 158 healthy control participants underwent a fasting blood draw to test for PC and MPV along with a comprehensive laboratory examination. The International Erectile Function Index was used to diagnose ED. Genetic variants of ED were obtained from individuals of European ancestry including 6175

SUBMITTER: Peng J 

PROVIDER: S-EPMC11723799 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature