Functional connectivity associations with menstrual pain characteristics in adolescents: an investigation of the triple network model.

ABSTRACT:

Abstract

Menstrual pain is associated with deficits in central pain processing, yet neuroimaging studies to date have all been limited by focusing on group comparisons of adult women with vs without menstrual pain. This study aimed to investigate the role of the triple network model (TNM) of brain networks in adolescent girls with varied menstrual pain severity ratings. One hundred participants (ages 13-19 years) completed a 6-min resting state functional magnetic resonance imaging (fMRI) scan and rated menstrual pain severity, menstrual pain interference, and cumulative menstrual pain exposure. Imaging analyses included age and gynecological age (years since menarche) as covariates. Menstrual pain severity was positively associated with functional connectivity between the cingulo-

SUBMITTER: Payne LA 

PROVIDER: S-EPMC11723811 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature