The TRIM37 variant rs57141087 contributes to triple-negative breast cancer outcomes in Black women.

ABSTRACT: Triple-negative breast cancer (TNBC) disproportionately affects younger Black women, who show more aggressive phenotypes and poorer outcomes than women of other racial identities. While the impact of socioenvironmental inequities within and beyond health systems is well documented, the genetic influence in TNBC-associated racial disparities remains elusive. Here, we report that cancer-free breast tissue from Black women expresses TRIM37 at a significantly higher level relative to White women. A reporter-based screen for regulatory variants identifies a non-coding risk variant rs57141087 in the 5' gene upstream region of the TRIM37 locus with enhancer activity. Mechanistically, rs57141087 increases enhancer-promoter interactions through NRF1, resulting in stronger TRIM37 promoter activity.

SUBMITTER: Tihagam RD 

PROVIDER: S-EPMC11723928 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature