Novel integrated multiomics analysis reveals a key role for integrin beta-like 1 in wound scarring.

ABSTRACT: Exacerbation of scarring can originate from a minority fibroblast population that has undergone inflammatory-mediated genetic changes within the wound microenvironment. The fundamental relationship between molecular and spatial organization of the repair process at the single-cell level remains unclear. We have developed a novel, high-resolution spatial multiomics method that integrates spatial transcriptomics with scRNA-Seq; we identified new characteristic features of cell-cell communication and signaling during the repair process. Data from PU.1^-/- mice, which lack an inflammatory response, combined with scRNA-Seq and Visium transcriptomics, led to the identification of nine genes potentially involved in inflammation-related scarring, including integrin beta-like 1 (Itgbl1).

SUBMITTER: Kim SE 

PROVIDER: S-EPMC11724056 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature