Medical history predicts phenome-wide disease onset and enables the rapid response to emerging health threats.

ABSTRACT: The COVID-19 pandemic exposed a global deficiency of systematic, data-driven guidance to identify high-risk individuals. Here, we illustrate the utility of routinely recorded medical history to predict the risk for 1741 diseases across clinical specialties and support the rapid response to emerging health threats such as COVID-19. We developed a neural network to learn from health records of 502,489 UK Biobank participants. Importantly, we observed discriminative improvements over basic demographic predictors for 1546 (88.8%) endpoints. After transferring the unmodified risk models to the All of US cohort, we replicated these improvements for 1115 (78.9%) of 1414 investigated endpoints, demonstrating generalizability across healthcare systems and historically underrepresented groups. Ultim

SUBMITTER: Steinfeldt J 

PROVIDER: S-EPMC11724087 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature