Genome-Wide Association Study Reveals a Causal Relationship Between Allergic Rhinitis and Hazelnut Allergy.

ABSTRACT:

Background

Little is known about the genetics of food allergy (FA) to various allergens and the heterogeneity of FA in adults.

Objective

We aimed to investigate genetic susceptibility to FA in an adult population and to assess the association between secondary FA and allergic rhinitis (AR).

Methods

FA and allergen-specific FA were defined based on in-depth questionnaires and a previously published FA algorithm in the Lifelines. We performed a series of genome-wide association studies (GWAS) on FA and nine allergen-specific (e.g., hazelnut) FA in 21,353 adults in Lifelines. Single nucleotide polymorphisms (SNPs) (p < 1E-5) were replicated in a second independent set of 15,518 adults participating in the Lifelines followed by meta-analysis of the results of the two data

SUBMITTER: Sun Y 

PROVIDER: S-EPMC11724235 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature