Basophil activation test is a complementary tool in the diagnosis of immediate reactions to platinum salts and taxanes.

ABSTRACT:

Background

Delabelling pathways offer confirmatory diagnosis and can prevent unnecessary second-line therapies or drug desensitization procedures after chemotherapeutic hypersensitivity reactions (CHT-HSRs). However, these pathways rely on risky in vivo tests. Data on whether in vitro tests could be helpful are scarce. We assessed the role of basophil activation test (BAT) in the diagnosis of HSRs to platin salts (PSs) and taxanes (TXs) in a well-defined population featuring varied endophenotypes and severities of HSRs.

Methods

We conducted a 3-year-long multicentric, prospective study with 121 suspected-immediate CHT-HSR patients. The allergy workup included clinical history (initial reaction based on Type I, cytokine release syndrome, and mixed phenotype's symptoms and if

SUBMITTER: Bogas G 

PROVIDER: S-EPMC11724245 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature