Food Allergy Genetics and Epigenetics: A Review of Genome-Wide Association Studies.

ABSTRACT: In this review, we provide an overview of food allergy genetics and epigenetics aimed at clinicians and researchers. This includes a brief review of the current understanding of genetic and epigenetic mechanisms, inheritance of food allergy, as well as a discussion of advantages and limitations of the different types of studies in genetic research. We specifically focus on the results of genome-wide association studies in food allergy, which have identified 16 genetic variants that reach genome-wide significance, many of which overlap with other allergic diseases, including asthma, atopic dermatitis, and allergic rhinitis. Identified genes for food allergy are mainly involved in epithelial barrier function (e.g., FLG, SERPINB7) and immune function (e.g., HLA, IL4). Epigenome-wide significa

SUBMITTER: Arnau-Soler A 

PROVIDER: S-EPMC11724255 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature