Motif distribution in genomes gives insights into gene clustering and co-regulation.

ABSTRACT: We read the genome as proteins in the cell would - by studying the distributions of 5-6 base motifs of DNA in the whole genome or smaller stretches such as parts of, or whole chromosomes. This led us to some interesting findings about motif clustering and chromosome organization. It is quite clear that the motif distribution in genomes is not random at the length scales we examined: 1 kb to entire chromosomes. The observed-to-expected (OE) ratios of motif distributions show strong correlations in pairs of chromosomes that are susceptible to translocations. With the aid of examples, we suggest that similarity in motif distributions in promoter regions of genes could imply co-regulation. A simple extension of this idea empowers us with the ability to construct gene regulatory networks. Furth

SUBMITTER: Chakraborty A 

PROVIDER: S-EPMC11724300 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature