PRMT5 inhibition has a potent anti-tumor activity against adenoid cystic carcinoma of salivary glands.

ABSTRACT:

Background

Adenoid cystic carcinoma (ACC) is a rare glandular malignancy, commonly originating in salivary glands of the head and neck. Given its protracted growth, ACC is usually diagnosed in advanced stage. Treatment of ACC is limited to surgery and/or adjuvant radiotherapy, which often fails to prevent disease recurrence, and no FDA-approved targeted therapies are currently available. As such, identification of new therapeutic targets specific to ACC is crucial for improved patients' outcomes.

Methods

After thoroughly evaluating the gene expression and signaling patterns characterizing ACC, we applied PandaOmics (an AI-driven software platform for novel therapeutic target discovery) on the unique transcriptomic dataset of 87 primary ACCs. Identifying protein arginine meth

SUBMITTER: Mishra V 

PROVIDER: S-EPMC11724466 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature