The periplasmic protein HslJ is the first-line of defense against oxidative stress in Acinetobacter baumannii.

ABSTRACT:

Background

Acinetobacter baumannii poses a significant threat globally, causing infections primarily in healthcare settings, with high mortality rates. Its adaptability to antibiotic resistance and tolerance to various stresses, including reactive oxygen species (ROS), contribute to its persistence in healthcare environments. Previous evidence suggested that the periplasmic heat shock protein, HslJ-like protein (ABUW_2868), could be involved in oxidative stress defense in A. baumannii. In this study, we demonstrate the pivotal function of HslJ as the first line of defense against oxidative damage induced by hydrogen peroxide (H₂O₂).

Methods

An isogenic site-specific hslJ mutant of A. baumannii AB5075 was used to evaluate its sensitivity to H₂

SUBMITTER: Scribano D 

PROVIDER: S-EPMC11724541 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature