Suppression of mycotoxins production and efficient chelation of heavy metals using natural melanin originated from Aspergillus flavus and Aspergillus carbonarius.

ABSTRACT:

Background

This study employed melanin synthesized by Aspergillus flavus and Aspergillus carbonarius to inhibit the production of mycotoxins and bioremediation of heavy metals (HMs).

Methods

First, twenty fungal isolates were obtained from soil samples, and were evaluated to produce melanin. The melanin of the most potent producers has undergone several confirmatory experiments, including, Dihydroxyphenylalanine (DOPA)-inhibitor-kojic acid pathway detection, High-performance liquid chromatography (HPLC), Fourier-transform infrared (FTIR) and Nuclear magnetic resonance (NMR). Additionally, the melanin production culture conditions were optimized. The antioxidant activity of melanin was detected with 1,1-Diphenyl-2-picrylhydrazyl (DPPH). HPLC was used to measure the mycotoxins

SUBMITTER: El-Gazzar N 

PROVIDER: S-EPMC11724575 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature