α-Amylase inhibitory potential of dihydropyrano coumarins: In silico and DFT analysis.

ABSTRACT: Coumarin derivatives are one of the naturally occurring bioactive molecule. Dihydropyrano coumarins are one of the medicinally important derivatives of coumarin which have been reported to exhibit various bioactivity. However, there are no reports on their antihyperglycemic activities. Herein, we report their antihyperglycemic potential through α-Amylase inhibition. In this study, a series of 24 derivatives of dihydropyrano coumarins was synthesized and studied for alpha-Amylase inhibitory activity. All the derivatives of dihydropyrano coumarins (4a-x) were screened via molecular docking studies against human pancreatic alpha-Amylase (PDB id: 2QV4) followed by DNS assay to check their α-Amylase inhibitory potential. Six derivatives with o-chloro(4b), o-nitro(4c), p-nit

SUBMITTER: Garg P 

PROVIDER: S-EPMC11724822 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature