Specifically targeted antimicrobial peptides synergize with bacterial-entrapping peptide against systemic MRSA infections.

ABSTRACT:

Introduction

The design of precision antimicrobials aims to personalize the treatment of drug-resistant bacterial infections and avoid host microbiota dysbiosis.

Objectives

This study aimed to propose an efficient de novo design strategy to obtain specifically targeted antimicrobial peptides (STAMPs) against methicillin-resistant Staphylococcus aureus (MRSA).

Methods

We evaluated three strategies designed to increase the selectivity of antimicrobial peptides (AMPs) for MRSA and mainly adopted an advanced hybrid peptide strategy. First, we proposed a traversal design to generate sequences, and constructed machine learning models to predict the anti-S. aureus activity levels of unknown peptides. Subsequently, six peptides were predicted to have high activity, among whic

SUBMITTER: Xu B 

PROVIDER: S-EPMC11725144 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature