Core fucosylation regulates the ovarian response via FSH receptor during follicular development.

ABSTRACT:

Introduction

Ovarian low response to follicle-stimulating hormone (FSH) causes infertility featuring hypergonadotropic hypogonadism, ovarian failure, and/or defective ovarian response.

Objectives

N-glycosylation is essential for FSH receptor (FSHR). Core fucosylation catalyzed by fucosyltransferase 8 (FUT8) is the most common N-glycosylation. Core fucosylation level changes between individuals and plays important roles in multiple physiological and pathological conditions. This study aims to elucidate the significance of FUT8 to modulate FSHR function in female fertility.

Methods

Samples from patients classified as poor ovary responders (PORs) were detected with lectin blot and real-time PCR. Fut8 gene knockout (Fut8^-/-) mice and FUT8-knockdown human granul

SUBMITTER: Wang T 

PROVIDER: S-EPMC11725149 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature