Glycosidic linkages of fungus polysaccharides influence the anti-inflammatory activity in mice.

ABSTRACT:

Introduction

Over decades, the source-function relationships of bioactive polysaccharides have been progressively investigated, however, it is still unclear how a defined structure may conduce to the bioactivities of polysaccharides.

Objectives

To explore the structure-function relationship of fungus polysaccharides, we employed a dextran sulfate sodium (DSS)-induced colitis mouse model to compare the anti-inflammatory activity of two fungus polysaccharides from Dictyophora indusiata (DIP) and Tremella fuciformis (TFP), which exhibit distinct glycosidic linkages.

Methods

The structures of DIP and TFP were characterized through molecular weight detection, molecular morphology analysis, methylation analysis, and NMR analysis. Subsequently, we employed a DSS-induced coli

SUBMITTER: Yuan Q 

PROVIDER: S-EPMC11725157 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature