Biological characterization and clinical significance of cuproptosis-related genes in lung adenocarcinoma.

ABSTRACT:

Background

Lung cancer has high morbidity and mortality rates, which results in a poor prognosis. Cuproptosis is a novel cell death mechanism. The aim of this study was to examine the biological characteristics and clinical significance of genes associated with cuproptosis in lung adenocarcinoma (LUAD), and to understand the molecular mechanisms underlying the occurrence and progression of LUAD.

Methods

We targeted 10 cuproptosis-related genes from previous studies and used the datasets from GEO and TCGA databases to identify differential genes related to cuproptosis; then the data were analyzed by R package, Cytoscape, TISDB, cBioPortal, STRING, CancerSEA, and Disgenet; and finally, the data were detected by immunohistochemistry validation was performed.

Results

CDKN

SUBMITTER: Li M 

PROVIDER: S-EPMC11725195 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature