Potential effect of immediate postpartum use of injectable contraception on lactogenesis.

ABSTRACT:

Objectives

We evaluated the effect of immediate postpartum use of depot medroxyprogesterone acetate (DMPA) on the timing of lactogenesis stage II (LS-II).

Study design

The initial design randomly assigned adults who delivered a full-term infant in 2019-2021 to receive within 48 hours of delivery: (1) DMPA, (2) placebo injection, or (3) no injection. Due to low enrollment, we changed in 2021-2023 to a nonrandomized design using matching at recruitment for obesity and delivery method and propensity score weighting for analysis. We combined data from both designs to compare immediate postpartum DMPA use (N = 55) vs control (placebo or no injection) group (N = 95). We defined noninferiority a priori as being met if the upper bound of a two-sided 95% CI for mean difference in tim

SUBMITTER: Gallo MF 

PROVIDER: S-EPMC11725434 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature