Clinical and prognostic significance of CD27 and CD44 expression patterns in Egyptian pediatric patients with B-precursor acute lymphoblastic leukemia.

ABSTRACT:

Introduction

The expression pattern of CD27 and CD44 was found to correlate with the differentiation stages of B cell precursors, which were known to be involved in a variety of immunological responses.

Aim of the study

This study aimed to determine the biological significance of CD27 and CD44 expression in patients with B-precursor acute lymphoblastic leukemia (B-ALL), as well as their association with standard prognostic factors and therapeutic response.

Patients and methods

This case-control study included 60 pediatric patients newly diagnosed with B-ALL and 30 pediatric controls. The patient CD27 and CD44 levels were measured using the Beckman Coulter Navios Flow Cytometer.

Results

Most malignant cells (91.6 %) expressed CD44, but only 50 % of the patients

SUBMITTER: Abobakr A 

PROVIDER: S-EPMC11726023 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature