Effects of therapy in experimental models of Peyronie's disease: a scoping review.

ABSTRACT:

Background

Peyronie's disease (PD) is a fibrotic disorder affecting the penile tunica albugínea, with unclear pathophysiology despite centuries of recognition.

Aim

This scoping review maps the effects of interventions in basic PD research, synthesizing evidence from in vivo and in vitro studies to guide future investigation.

Methods

In October-November 2023, a systematic search was conducted across PubMed, Embase (Ovid), Science of Web, and Scopus, following SRYCLE's guidelines. Relevant studies were screened for data on interventions targeting PD in vivo and in vitro, with no language or time restrictions.

Outcomes

Primary outcomes included changes in extracellular matrix (ECM) proteins, myofibroblast activity, and plaque size.

Results

Of 683 articles s

SUBMITTER: Wiborg MH 

PROVIDER: S-EPMC11726063 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature