Acute myeloid leukemia-derived bone marrow mesenchymal cells exhibit improved support for leukemic cell proliferation.

ABSTRACT:

Introduction

The bone marrow (BM) microenvironment plays a significant role in acute myeloid leukemia (AML) genesis and there is evidence that BM mesenchymal stromal cells (BMMSCs) can support leukemia progenitor cell proliferation and survival and provide resistance to cytotoxic therapies.

Hypothesis and method

Nevertheless, currently unknown are the relevance of the spatial localization of AML cells relative to the BMMSCs and whether BMMSCs from patients with AML and healthy subjects have similar properties. To address these issues, we performed a differential gene expression analysis using RNA-sequencing data generated from healthy donors (HDs) and leukemic BMMSCs.

Results

The Gene Set Enrichment Analysis (GSEA) revealed that leukemic BMMSCs were associated with th

SUBMITTER: do Nascimento MC 

PROVIDER: S-EPMC11726071 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature