The survivin/XIAP suppressant YM155 impairs clonal growth and induces apoptosis in JAK2^V617F cells.

ABSTRACT: The central role of the control of apoptosis in the pathophysiology of Philadelphia chromosome-negative myeloproliferative neoplasms has recently been reinforced in genetic and pharmacological studies. The inhibitor of apoptosis protein family has eight members and plays an important role in apoptosis, with the most studied being survivin (BIRC5) and X-linked inhibitor of apoptosis (XIAP). YM155 is a small molecule with antineoplastic potential that has been described as a suppressant of survivin and XIAP. In the present study, BIRC5 expression was significantly increased in primary myelofibrosis patients compared to healthy donors. On the other hand, XIAP expression was reduced in myeloproliferative neoplasms patients. In JAK2^V617F cells, YM155 reduces cell viability and autono

SUBMITTER: Carlos JAEG 

PROVIDER: S-EPMC11726093 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature