Evaluation of blood cell count using an automatic hematology analyzer to optimize collection of peripheral blood progenitor cells by leukapheresis.

ABSTRACT:

Background

Autologous stem cell transplantation is a treatment modality for several diseases. Prediction of successful mobilization may be useful to optimize hematopoietic stem cell collection.

Study design and methods

This was a retrospective study with data from transplantation candidates between September 2015 and December 2021 being analyzed. The medical record of each patient was reviewed to mine mobilization information. The laboratory data analyzed were CD34⁺ cell enumeration and pre-collection peripheral blood cell count. The primary outcome, good mobilization, was defined as a CD34⁺ cell count ≥20/μL.

Results

This study included 807 patients. Increased patient weight, low mean corpuscular volume, high nucleated red blood cells, periphera

SUBMITTER: Pederzoli PRMP 

PROVIDER: S-EPMC11726100 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature