NT157 exhibits antineoplastic effects by targeting IRS and STAT3/5 signaling in multiple myeloma.

ABSTRACT: Multiple myeloma (MM) is a prevalent hematological malignancy with high recurrence and no definitive cure. The current study revisits the role of the IGF1/IGF1R axis in MM, introducing a novel inhibitor, NT157. The IGF1/IGF1R pathway is pivotal in MM, influencing cell survival, proliferation, and migration and impacting patient survival outcomes. NT157 targets intracellular proteins such as IRS and STAT proteins and demonstrates antineoplastic potential in hematological malignancies and solid tumors. In the present study, we assessed IGF1R signaling-related gene expression in MM patients and healthy donors, unveiling significant distinctions. MM cell lines displayed varying expression patterns of IGF1R-related proteins. A gene dependence analysis indicated the importance of targeting recep

SUBMITTER: de Queiroz GN 

PROVIDER: S-EPMC11726112 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature