LGALS4 inhibits glycolysis and promotes apoptosis of colorectal cancer cells via β‑catenin signaling.

ABSTRACT: Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide. Glycolysis serves a crucial role in the development of CRC. The aim of the present study was to investigate the function of lectin galactoside-binding soluble 4 (LGALS4) in the regulation of glycolysis and its therapeutic potential in CRC. In the present study, 175 overlapping differentially expressed genes were identified by comprehensive analysis of The Cancer Genome Atlas database and the GSE26571 CRC dataset from the Gene Expression Omnibus database. LGALS4 was identified as the central gene by prognostic analysis using the mimetic map construction method and least absolute shrinkage and selection operator Cox regression. In vitro experiments were performed to evaluate the effe

SUBMITTER: Li S 

PROVIDER: S-EPMC11726281 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature