Analysis of HER2 expression changes from breast primary to brain metastases and the impact of HER2-low expression on overall survival.

ABSTRACT:

Background

There are limited data regarding HER2-low expression dynamics between matched primary tumors and brain metastases (BrMs) in breast cancer. HER2-low expression has emerged as a new therapeutic biomarker for highly active antibody-drug conjugates with emerging intracranial activity.

Methods

Patients with metastatic breast cancer and BrMs seen at an NCI-designated center between 2003 and 2023 were identified. HER2 expression was defined as HER2-positive (3+, 2+/ISH amplified), HER2-low (1+, 2+/ISH negative), or HER2-0 by ASCO-CAP guidelines. Estrogen receptor (ER) status was defined as ER ≥1%. Multivariate survival analyses by Cox proportional hazard models were determined from the time of BrM resection to death or last follow-up between the 3 subtypes, controlling f

SUBMITTER: Pereslete AM 

PROVIDER: S-EPMC11726339 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature