Meningeal solitary fibrous tumor cell states phenocopy cerebral vascular development and homeostasis.

ABSTRACT:

Background

Meningeal solitary fibrous tumors (SFTs) are rare mesenchymal neoplasms that are associated with local recurrence and hematogenous metastasis. The cell states and spatial transcriptomic architecture underlying the unique clinical behavior of meningeal SFTs are unknown.

Methods

Single-cell (n = 4), spatial (n = 8), and bulk RNA sequencing (n = 22) were used to define the cell states and spatial transcriptomic architecture of meningeal SFTs across histological grades and in patient-matched pairs of primary/recurrent or intracranial/metastatic samples. Immunofluorescence, immunohistochemistry, and comparison of single-cell types to meningiomas, or to cerebral vascular development or homeostasis, were used for validation.

Results

Here we show meningeal SFTs are

SUBMITTER: Mirchia K 

PROVIDER: S-EPMC11726342 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature