Activation of Wnt/β-catenin signaling is critical for the tumorigenesis of choroid plexus.

ABSTRACT:

Background

The choroid plexus (ChP) is the secretory epithelial structure located in the brain ventricles. Choroid plexus tumors (CPTs) are rare neoplasms predominantly occurring in young patients with intensified malignancy in children. CPT treatment is hindered by insufficient knowledge of tumor pathology and the limited availability of valid models.

Methods

Genomic and transcriptomic data from CPT patients were analyzed to identify the putative pathological pathway. Cellular and molecular techniques were employed to validate bioinformatic results in CPT patient samples. Pharmacologic inhibition of Wnt/β-catenin signaling was assessed in CPT cells. Cell-based assays of ChP cell lines were performed following CRISPR-Cas9-derived knockout and overexpression of Wnt/β-catenin

SUBMITTER: Ho KH 

PROVIDER: S-EPMC11726344 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature