Asoprisnil as a Novel Ligand Interacting with Stress-Associated Glucocorticoid Receptor.

ABSTRACT: Background/objective: The glucocorticoid receptor (GR) is critical in regulating cortisol production during stress. This makes it a key target for treating conditions associated with hypothalamic-pituitary-adrenal (HPA) axis dysregulation, such as mental disorders. This study explores novel ligands beyond mifepristone for their potential to modulate GR with improved efficacy and safety. By investigating these interactions, we seek to identify new pharmacotherapeutic options for stress-related mental illness. Methods: The ligands asoprisnil, campestanol, and stellasterol were selected based on structural similarities to mifepristone (reference ligand) and evaluated for pharmacological and ADME (absorption, distribution, metabolism, and excretion) properties using the SwissADME

SUBMITTER: Ejiohuo O 

PROVIDER: S-EPMC11726916 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature