High-Risk Lineages of Hybrid Plasmids Carrying Virulence and Carbapenemase Genes.

ABSTRACT: Background/Objectives: Carbapenem-resistant Enterobacterales (CRE) are a global health threat due to their high morbidity and mortality rates and limited treatment options. This study examines the plasmid-mediated transmission of virulence and antibiotic resistance determinants in carbapenem-resistant Klebsiella pneumoniae (Kpn) and Escherichia coli (E. coli) isolated from Russian hospitals. Methods: We performed short- and long-read whole-genome sequencing of 53 clinical isolates (48 Kpn and 5 E. coli) attributed to 15 genetic lineages and collected from 21 hospitals across nine Russian cities between 2016 and 2022. Results: The plasmid analysis identified 18 clusters that showed high concordance with replicon typing, w

SUBMITTER: Shapovalova VV 

PROVIDER: S-EPMC11726917 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature