Mfsd2a suppresses colorectal cancer progression and liver metastasis via the S100A14/STAT3 axis.

ABSTRACT:

Background

Colorectal cancer (CRC) exhibits a high incidence globally, with the liver being the most common site of distant metastasis. At the time of diagnosis, 20-30% of CRC patients already present with liver metastases. Colorectal liver metastasis (CRLM) is a major cause of mortality among CRC patients. The pathogenesis of CRLM involves complex molecular mechanisms and the hepatic immune microenvironment, but current clinical prevention and treatment are significantly limited. Recent studies have revealed that the major facilitator superfamily domain containing protein-2a (Mfsd2a) plays a pivotal role in the development and metastasis of various cancers. For instance, Mfsd2a inhibits gastric cancer initiation and progression and may impact angiogenesis. However, the mechanisms

SUBMITTER: Sun L 

PROVIDER: S-EPMC11726956 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature