Klebsiella pneumoniae-derived extracellular vesicles impair endothelial function by inhibiting SIRT1.

ABSTRACT:

Background

The potential role of Klebsiella pneumoniae (K.pn) in hypertension development has been emphasized, although the specific mechanisms have not been well understood. Bacterial extracellular vesicles (BEVs) released by Gram-negative bacteria modulate host cell functions by delivering bacterial components to host cells. Endothelial dysfunction is an important early event in the pathogenesis of hypertension, yet the impact of K.pn-secreted EVs (K.pn EVs) on endothelial function remains unclear. This study aimed to investigate the effects of K.pn EVs on endothelial function and to elucidate the underlying mechanisms.

Methods

K.pn EVs were purified from the bacterial suspension using ultracentrifugation and characterized by transmission electron microscopy nanoparticle t

SUBMITTER: Li X 

PROVIDER: S-EPMC11726972 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature