N⁶-Methyladenosine Regulates Cilia Elongation in Cancer Cells by Modulating HDAC6 Expression.

ABSTRACT: Primary cilia are microtubule-based organelles that function as cellular antennae to address multiple metabolic and extracellular cues. The past decade has seen significant advances in understanding the pro-tumorigenic role of N⁶-methyladenosine (m⁶A) modification in tumorigenesis. Nevertheless, whether m⁶A modification modulates the cilia dynamics during cancer progression remains unclear. Here, the results show that m⁶A methyltransferase METTL3 regulates cilia length in cancer cells via HDAC6-dependent deacetylation of axonemal α-tubulin, thereby controlling cancer development. Mechanically, METTL3 positively regulates the translation of HDAC6 in an m⁶A-dependent manner, while m⁶A methylation of A3678 in the coding sequenc

SUBMITTER: Rui Y 

PROVIDER: S-EPMC11727115 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature