Investigating the impact of microbiome-changing interventions on food decision-making: MIFOOD study protocol.

ABSTRACT:

Background

Obesity is a multifactorial disease reaching pandemic proportions with increasing healthcare costs, advocating the development of better prevention and treatment strategies. Previous research indicates that the gut microbiome plays an important role in metabolic, hormonal, and neuronal cross-talk underlying eating behavior. We therefore aim to examine the effects of prebiotic and neurocognitive behavioral interventions on food decision-making and to assay the underlying mechanisms in a Randomized Controlled Trial (RCT).

Method

This study uses a parallel arm RCT design with a 26-week intervention period. We plan to enroll 90 participants (male/diverse/female) living with overweight or obesity, defined as either a Waist-to-Hip Ratio (WHR) ≥ 0.9 (male)/0.85 (diverse,

SUBMITTER: Vartanian M 

PROVIDER: S-EPMC11727427 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature