Genetic determinants of silver nanoparticle resistance and the impact of gamma irradiation on nanoparticle stability.

ABSTRACT:

Background

One of the main issues facing public health with microbial infections is antibiotic resistance. Nanoparticles (NPs) are among the best alternatives to overcome this issue. Silver nanoparticle (AgNPs) preparations are widely applied to treat multidrug-resistant pathogens. Therefore, there is an urgent need for greater knowledge regarding the effects of improper and excessive use of these medications. The current study describes the consequences of long-term exposure to sub-lethal concentrations of AgNPs on the bacterial sensitivity to NPs and the reflection of this change on the bacterial genome.

Results

Chemical methods have been used to prepare AgNPs and gamma irradiation has been utilized to produce more stable AgNPs. Different techniques were used to characteri

SUBMITTER: Mahfouz AM 

PROVIDER: S-EPMC11727503 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature