Deformed wing virus coopts the host arginine kinase to enhance its fitness in honey bees (Apis mellifera).

ABSTRACT:

Background

Deformed wing virus (DWV) is a major honey bee pathogen that is actively transmitted by the parasitic mite Varroa destructor and plays a primary role in Apis mellifera winter colony losses. Despite intense investigation on this pollinator, which has a unique environmental and economic importance, the mechanisms underlying the molecular interactions between DWV and honey bees are still poorly understood. Here, we report on a group of honey bee proteins, identified by mass spectrometry, that specifically co-immunoprecipitate with DWV virus particles.

Results

Most of the proteins identified are involved in fundamental metabolic pathways. Among the co-immunoprecipitated proteins, one of the most interesting was arginine kinase (ArgK), a conserved protein playing multi

SUBMITTER: Becchimanzi A 

PROVIDER: S-EPMC11727705 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature