Synthesis estimators for transportability with positivity violations by a continuous covariate.

ABSTRACT: Studies intended to estimate the effect of a treatment, like randomized trials, may not be sampled from the desired target population. To correct for this discrepancy, estimates can be transported to the target population. Methods for transporting between populations are often premised on a positivity assumption, such that all relevant covariate patterns in one population are also present in the other. However, eligibility criteria, particularly in the case of trials, can result in violations of positivity when transporting to external populations. To address nonpositivity, a synthesis of statistical and mathematical models can be considered. This approach integrates multiple data sources (e.g. trials, observational, pharmacokinetic studies) to estimate treatment effects, leveraging mathem

SUBMITTER: Zivich PN 

PROVIDER: S-EPMC11728055 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature