Gastric microbiome composition accompanied with the <i>Helicobacter pylori</i> related DNA methylation anomaly.

ABSTRACT: Aim: DNA methylation is associated with gastric cancer and Helicobacter pylori (H. pylori) infection, while increasing evidence indicated involvement of other microbes reside in gastric mucosa during gastric tumorigenesis. We investigated bacterial communities in the gastric mucosa accompanied with H. pylori related methylation anomaly.Materials & methods: Gastric mucosa samples from antrum were obtained from 182 cancer-free patients. Bacterial communities were evaluated using 16S rRNA sequencing. The result was correlated with H. pylori related promoter CpG island (CGI) methylation of five genes (IGF2, SLC16A12, SOX11, P2RX7 and MYOD1), LINE1 hypomethylation and telomere length.Results & conclusion: We showed correlation between lowe

SUBMITTER: Shijimaya T 

PROVIDER: S-EPMC11728328 | biostudies-literature | 2024 Nov-Nov

REPOSITORIES: biostudies-literature