Growth in children with nephrotic syndrome: a post hoc analysis of the NEPTUNE study.

ABSTRACT:

Background

Steroids, the mainstay of treatment for nephrotic syndrome in children, have multiple adverse effects including growth suppression.

Methods

Anthropometric measurements in children < 18 years enrolled in the Nephrotic Syndrome Study Network (NEPTUNE) were collected. The longitudinal association of medication exposure and nephrotic syndrome characteristics with height z-score and growth velocity was determined using adjusted Generalized Estimating Equation regression and linear regression.

Results

A total of 318 children (57.2% males) with a baseline age of 7.64 ± 5.04 years were analyzed. The cumulative steroid dose was 216.4 (IQR 61.5, 652.7) mg/kg (N = 233). Overall, height z-scores were not significantly different at the last follow-up compared to baselin

SUBMITTER: Maniar A 

PROVIDER: S-EPMC11728624 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature