Associations of high-sensitivity C-reactive protein with neuropsychological outcomes and cerebral white matter hyperintensities in older adults at risk of dementia.

ABSTRACT: Inflammation is becoming increasingly recognised as a core feature of dementia with evidence indicating that its role may vary and adapt across different stages of the neurodegenerative process. This study aimed to investigate whether the associations of high-sensitivity C-reactive protein (hs-CRP) with neuropsychological performance (verbal memory, executive function, processing speed) and cerebral white matter hyperintensities (WMHs) differed between older adults with subjective cognitive decline (SCD; n = 179) and mild cognitive impairment (MCI; n = 286). Fasting serum hs-CRP concentrations were grouped into low (<1.0 mg/L), moderate (1.0-3.0 mg/L), and high (>3.0-10.0 mg/L). Structural MRI scans were used to estimate WMH lesion volumes in the whole brain, as well as periv

SUBMITTER: Yu R 

PROVIDER: S-EPMC11728901 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature